Accurate SHAPE‐directed RNA structure prediction
نویسندگان
چکیده
منابع مشابه
Computational RNA Structure Prediction
The view of RNA as simple information transfer molecule has been continuously challenged since the discovery of ribozymes, a class of RNA molecules with enzyme-like function. Moreover, the recent discovery of tiny RNA molecules such as RNAs and small interfering RNA, is transforming our thinking about how gene expression is regulated. Thus, RNA molecules are now known to carry a large repertory...
متن کاملRNA Secondary Structure Prediction.
In this unit, protocols are provided for predicting RNA secondary structure with the user-friendly RNAstructure desktop computer program and the RNAstructure Web server. The minimum free energy structure and a set of suboptimal structures with similar free energies are predicted. Prediction of high-affinity oligonucleotide binding sites to a structured RNA target is also presented. © 2016 by Jo...
متن کاملRna Secondary Structure Prediction
Understanding secondary structures of RNAs helps to determine their chemical and biological properties. Only a small number of RNA structures have been determined currently since such structure determination experiments are timeconsuming and expensive. As a result, scientists start to rely on RNA secondary structure prediction. Unlike protein structure prediction, predicting RNA secondary struc...
متن کاملRNA-SSPT: RNA Secondary Structure Prediction Tools
The prediction of RNA structure is useful for understanding evolution for both in silico and in vitro studies. Physical methods like NMR studies to predict RNA secondary structure are expensive and difficult. Computational RNA secondary structure prediction is easier. Comparative sequence analysis provides the best solution. But secondary structure prediction of a single RNA sequence is challen...
متن کاملAccurate SHAPE-directed RNA structure determination.
Almost all RNAs can fold to form extensive base-paired secondary structures. Many of these structures then modulate numerous fundamental elements of gene expression. Deducing these structure-function relationships requires that it be possible to predict RNA secondary structures accurately. However, RNA secondary structure prediction for large RNAs, such that a single predicted structure for a s...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.843.2